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Last Updated: Jul 20, 2026

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USMLE USMLE Exam Syllabus Topics:

TopicDetails
Topic 1
  • Adaptive behavioral responses to stress and illness
  • Biochemistry and molecular biology
Topic 2
  • Adverse effects of drugs on the hematologic and lymphoreticular systems
  • Disorders associated with immunodeficiency
Topic 3
  • Deficiency primarily of humoral immunity
  • Immunologic and inflammatory disorders
Topic 4
  • Infectious and inflammatory disorders of the eye
  • Adverse effects of drugs on the immune system
Topic 5
  • Cranial and peripheral nerve disorders
  • Cellular basis of the immune response and immunologic mediators
Topic 6
  • Maladaptive behavioral responses to stress and illness
  • Immunologic and inflammatory disorders
Topic 7
  • Biology of tissue response to disease
  • Disorders of balance and spatial orientation

Reference: http://www.usmle.org/step-1/#question-formats

USMLE Step 3 is open to candidates who already hold their USMLE Step 1 and Step 2 certificates. Step 3 is a two-day exam that assesses whether candidates are able apply medical knowledge and understanding of biomedical and clinical science essential to unsupervised medical practice. This is the final USMLE exam which leads to the license to practice medicine without supervision - the ultimate goal of medical students and professionals willing to practice medicine in the United States. Step 3 represents the final assessment of physicians assuming independent responsibility for delivering general medical care.

USMLE Step 2 is open to all medical students and graduates who have successfully passed the USMLE Step 1. The Step 2 exam assesses the candidates' medical knowledge, skills, and understanding of clinical science essential for patient treatment and care, health promotion and disease prevention.

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